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Not all CBD:THC pairings should be undertaken. For example, higher doses of CBD are required to offset the sedative effects of THC (Schwartz, 1992). This may be well suited for certain applications, such as mild insomnia, where sedation is a desired effect (although the latter is not necessarily the desired effect in heavy sedation practices). The potency of CBD:THC agent pairs should be determined to avoid overdose and overtemperament. For CB1-based therapy, tetrahydrocannabinolic acid (THCA) is the more potent, nonpsychoactive CBD acid. Epidiolex (cannabidiolic acid) is a weak CB1 agonist, whereas cannabidiol is a full CB1 agonist. CBD:THC ratios should be optimised to best balance these pharmacological properties. Whilst THC is an antagonist of the CB2 receptor, CBD is a CB2 agonist (Tetu et al., 2007) and antagonist. CBD binds to CB1, CB2, with a strong affinity, and GPR55, with a moderate affinity. CBD potentiates and enhances the effects of THC, whereas THC has little effect on the activity of CBD (Ohno et al., 2012). Whilst CBD:THC ratios of 1:1 have been seen to be most effective in the treatment of seizures in animal models (Robson et al., 2000), 1:100 is optimal for the treatment of anxiety and depression (Bergamaschi et al., 2012). A ratio of 1:2 or 2:1 CBD:THC has been reported as optimal for the treatment of anxiety (Hampson et al., 2009), whilst 1:4 CBD:THC has been shown to be therapeutic in a model of epilepsy (Robson et al., 2001).
Brousseau, J., De Meijer, E., & Jean, P. 2009. ‘‘Cannabidiol reduces hyperalgesia and inflammation in an animal model of neuropathic pain’’. Basic & Clinical Pharmacology & Toxicology 93(1):15-25.
A major challenge to the burgeoning cannabis research industry is the generation of easily-affordable cannabis products for medical and recreational use. Large-scale cultivation of cannabis plants under non-critical conditions is possible, and many nations now produce this product for internal markets. The ability to produce cannabis by other means, such as the more recent discovery of cannabinoids in the milk of cows (Wagner et al., 2008) and goats (Wagner et al., 2009) suggests new opportunities to produce THC as an ingredient in foods and beverages. The olive oil industry now includes cannabinoids as an additive for functional foods, and the potential to add THC to alkahestic substances is obvious. Indeed, the first such product, Havikol (Hunter Industries), now includes a trace concentration of THC.
I am running a PC with Windows 7 and Adobe Photoshop CS6. I am wondering how to end the trial period and convert to a full copy of Photoshop CS6. I tried closing down Photoshop, which produced a message telling me to return the disk. I did that, but the same message returned. How can I end this?
Hi Dave,I was able to get my English Indesign CS6 to switch to German. But there is one Problem. The moment I startet Indesign there is the error message that my trial version ends soon altough I bougt a regular Version with correct serial number by an adobe seller. Can anybody help me? 827ec27edc